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adcs  (ATCC)
97
ATCC adcs
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. <t>c,</t> <t>Cytotoxic</t> activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Adcs, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cytogen psma adc  (Cytogen Inc)
86
Cytogen Inc cytogen psma adc
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. <t>c,</t> <t>Cytotoxic</t> activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Cytogen Psma Adc, supplied by Cytogen Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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converter adc  (Texas Instruments)
86
Texas Instruments converter adc
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. <t>c,</t> <t>Cytotoxic</t> activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Converter Adc, supplied by Texas Instruments, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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adc 20  (Shanghai Medicilon)
86
Shanghai Medicilon adc 20
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. <t>c,</t> <t>Cytotoxic</t> activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Adc 20, supplied by Shanghai Medicilon, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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adc targets  (Ultivue Inc)
86
Ultivue Inc adc targets
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. <t>c,</t> <t>Cytotoxic</t> activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Adc Targets, supplied by Ultivue Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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adc 18  (Shanghai Medicilon)
86
Shanghai Medicilon adc 18
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. <t>c,</t> <t>Cytotoxic</t> activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Adc 18, supplied by Shanghai Medicilon, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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adc 19  (Shanghai Medicilon)
86
Shanghai Medicilon adc 19
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. <t>c,</t> <t>Cytotoxic</t> activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Adc 19, supplied by Shanghai Medicilon, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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chamber adc 2  (Camag)
86
Camag chamber adc 2
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. <t>c,</t> <t>Cytotoxic</t> activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Chamber Adc 2, supplied by Camag, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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claudin18 2 targeted adc  (Innovent Biologics)
86
Innovent Biologics claudin18 2 targeted adc
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. <t>c,</t> <t>Cytotoxic</t> activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Claudin18 2 Targeted Adc, supplied by Innovent Biologics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. c, Cytotoxic activity of ADCs in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.

Journal: bioRxiv

Article Title: De novo masking domains that gate TNF-family ligand assembly and activity

doi: 10.64898/2026.04.20.719557

Figure Lengend Snippet: The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. c, Cytotoxic activity of ADCs in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.

Article Snippet: Cytotoxic activity of ADCs was evaluated using SK-BR-3 human breast cancer cells (ATCC).

Techniques: Binding Assay, Isolation, Activation Assay, Construct, Functional Assay, In-Cell ELISA, Activity Assay, Control